Compact-molecule inhibitors with the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic form of cell Dying termed pyroptosis in mouse and human monocytes and macrophages1,two. In mouse myeloid cells, Dpp8/nine inhibition activates the inflammasome sensor Nlrp1b, which subsequently activates Professional-caspase-one to mediate cell death3, ne
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